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Hello!
We wanted to give you a quick intraday update on our new alert, NanoViricides, Inc. (NYSE American: NNVC).
NNVC opened today at 1.50 with a high so far of 1.54 – building a potential base for its next leg higher.
In May, following our previous alert, NNVC rallied +55%, reaching a high of 1.93 last week.
That is +28% above today’s open.
Now, we are watching for a continuation of the breakout higher.
NNVC has a 50 day moving average of 1.34 and a 20 day moving average of 1.60.
A breakout and close above this range could set in motion a much greater opportunity.
At the same time, as more investors continue to discover the company, attention may begin to shift.
Earlier in May, the company announced:
“NanoViricides, Inc. Has Filed its Quarterly Report - NV-387 Advancing for Phase II”
As the company further explained:
“We have chosen to first develop NV-387 for the treatment of MPox. Its more severe form, MPox Clade I, is endemic in African region, affecting entire population including children. The less severe form, MPox Clade II, has become endemic in the Western World, where it is primarily transmitted in Men-having-sex-with-men population.
There is no approved treatment for MPox viruses. Two drugs that were approved under the US FDA "Animal Rule", namely tecovirimat (TPOXX®, SIGA) and brincidofovir (TEMBEXA®, EBS) have been tried for MPox. Tecovirimat has failed in clinical trials to demonstrate efficacy over the standard of care. Brincidofovir has a black box warning and has known hepatotoxicity issues. Yet it was advanced into the MOSA clinical trial with first cohort dosed in January, 2025, It appears that further advancement beyond the initial cohort did not take place. A vaccine Jynneos, is FDA-approved for Smallpox and MPox. However, vaccine deployment logistics and costs are a major problem for developing countries such as DRC. Further, the effectiveness of 2-dose JYNNEOS vaccine against disease progression (not infection prevention) after 2-doses is only 66.6% in HIV negative subjects and 44.8% in HIV positive subjects, for MPox Clade II, based on US surveillance data (Lancet Infect Dis 2025; 25: 1106-15; https://doi.org/10.1016/ S1473-3099(25)00180- X). It is suggested that its efficacy against the more severe Clade I is likely even less.
We believe that the MPox clinical trial, if successful would help us advance NV-387 towards regulatory approval for Smallpox in the USA. Smallpox is considered an important bioterrorism agent. Two drugs have been stockpiled in the US Strategic National Stockpile for Smallpox preparedness, namely TPOXX and TEMBEXA, at the cost of billions of dollars. However, the virus can readily escape TPOXX by a single point mutation. TEMBEXA requires physician care during treatment, making it unsuitable as a bioterrorism response agent. Thus there is a need for a better antiviral agent.
Viruses cannot escape NV-387 because no matter how much a virus changes, it continues to bind to the sulfated proteoglycan attachment receptor(s) of the host which the virus needs to cause infection as well as for human-to-human transmission. NV-387 mimics the critical features of the conserved attachment receptors on the host-side that over 90% of viruses are known to use.”
Furthermore:
“We believe our regulatory developments for the orphan diseases and for bioterrorism agents response, provide for a rapid regulatory pathway for US FDA licensure of NV-387, with potential for non-dilutive grant and contracts funding, as well as possible direct US Government acquisition contracts worth hundreds of millions of dollars per year if NV-387 is approved for one of the agents that the US Government stockpiles drugs for. We believe that these early stage revenue opportunities would help us fuel the commercial drug development of NV-387 towards the tens of billions of dollars markets in RSV, Influenza, and other viral infections; as well as to further advance our NV-HHV-1 pan-herpesvirus drug candidate, among others.”
Last week, the company announced:
“In the Ebola Emergency, NV-387 is Ready to be Shipped to DRC, and It Compares Favorably as a Treatment for Ebola Versus Possible Options, Says NanoViricides”
As the company further explains:
“There were four drug candidates tested in a clinical trial in an Ebola Zaire outbreak, namely an antibody cocktail called ZMapp, another antibody cocktail called REGN-EB3, a monoclonal antibody developed from a survivor patient called mAb114, and a broad-spectrum nucleotide analog drug called Remdesivir. Of these, the more effective mAb114 (Ebanga) and REGN-EB3 (Inmazeb) were approved as treatments for Ebola Zaire infection, and the effect of ZMapp and Remdesivir against standard of care was not evaluated in the PALM clinical trial[3].
All of these four drugs require infusions, which is very difficult in a deadly disease such as Ebola that requires strong patient isolation protocols, and wherein protection of health care workers is of utmost important. Further, monoclonal antibodies are highly specific to the strain of virus and usually are not effective against unrelated strains.
Recently, a drug candidate, obeldesivir, was developed related to remdesivir[4]. Oral obeldesivir failed as a treatment for COVID-19 in a Phase III clinical trial[5].
This clinical failure raises substantial doubts that obeldesivir would be of any benefit in Ebola Bundibugyo infection, since the clinical activity of obeldesivir indeed appears to be less than that of remdesivir, Remdesivir was approved for COVID-19, but not for Ebola Zaire.
NV-387 was previously evaluated by the Company in animal models wherein a separate group of infected animals was treated with remdesivir to serve as a positive control. The increase in survival over untreated animals was 8.5 days (170%) for NV-387 IV, 4.4 days (88%) for NV-387 Oral, but only 2 days (40%) for Remdesivir IV in this uniformly lethal infection model for COVID-19[6]. This indicates that NV-387 IV as well as NV-387 PO were substantially superior to Remdesivir.
We believe these results of NV-387 being superior to Remdesivir as a treatment would hold for other viruses as well, including Ebola viruses.”
For a sustainable breakout higher, continue to watch for it to make higher lows and higher highs.
We are continuing to monitor NNVC for a sustainable breakout higher.
Happy Trading!
SmallCapStocks Team
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